Table of Contents

I. Introduction
A. What is Defitelio?
B. What is it Used to Treat?

II. Prescription Requirements
A. Do You Need a Prescription for Defitelio?

III. How Does Defitelio Work?

IV. Common Side Effects
A. What Are the Most Common Side Effects of Defitelio?

V. Interactions
A. What Should Not Be Taken with Defitelio?

VI. Prices, Coupons, and Copay
A. What Are the Prices, Coupons, and Copay for Defitelio?

Introduction

Defitelio is a prescription medication used to treat a rare blood disorder called veno-occlusive disease (VOD). VOD is a condition in which the veins in the liver become blocked, leading to a buildup of toxins in the body. Defitelio is an intravenous (IV) medication that is given to patients to help reduce the symptoms of VOD.

What is it Used to Treat?

Defitelio is used to treat veno-occlusive disease (VOD), a rare blood disorder. VOD is a condition in which the veins in the liver become blocked, leading to a buildup of toxins in the body. Symptoms of VOD can include fever, abdominal pain, jaundice, and a build-up of fluid in the abdomen. Defitelio is used to reduce the symptoms of VOD and help the body clear the toxins.

Do You Need a Prescription for Defitelio?

Yes, Defitelio is a prescription medication and must be prescribed by a doctor. It is not available over-the-counter and must be obtained through a pharmacy with a valid prescription.

How Does Defitelio Work?

Defitelio is an intravenous (IV) medication that is given to patients to help reduce the symptoms of VOD. The medication works by blocking the production of toxins in the body and helping the body to break down and clear the toxins. It also helps to reduce inflammation in the liver and improve blood flow.

What Are the Most Common Side Effects of Defitelio?

The most common side effects of Defitelio include nausea, vomiting, diarrhea, headache, fever, chills, and rash. Other less common side effects may include abdominal pain, dizziness, and difficulty breathing. If you experience any of these side effects, contact your doctor or healthcare provider immediately.

What Should Not Be Taken with Defitelio?

Defitelio should not be taken with other medications that can affect the liver, such as acetaminophen, ibuprofen, or aspirin. It is also important to tell your doctor about any other medications you are taking, including vitamins and supplements, to avoid any potential interactions.

What Are the Prices, Coupons, and Copay for Defitelio?

The cost of Defitelio can vary depending on your insurance plan and the pharmacy you use. Many insurance plans will cover the cost of Defitelio, but it is important to check with your insurance provider to see if it is covered. Some pharmacies may also offer coupons or discounts for Defitelio. It is also important to check with your doctor or healthcare provider to see if they offer any copay assistance programs for Defitelio.

Indications for Defitelio

Defitelio (defibrotide sodium) is a medication used to treat hepatic veno-occlusive disease (VOD) in adults and children who are undergoing hematopoietic stem cell transplantation (HSCT). It is used to reduce the risk of death due to VOD and to reduce the need for liver transplantation in adults and children.1

Dosage and Administration Recommendations

Defitelio is available as a solution for intravenous (IV) infusion. The recommended dose is 6.25 mg/kg/day given as a continuous IV infusion over 24 hours. The dose should be adjusted based on the patient’s body weight and the severity of the VOD.1

Common Drug Interactions

Defitelio is known to interact with other medications, such as anticoagulants, antiplatelet agents, and antifibrinolytics. It is important to tell your doctor about all other medications you are taking, including over-the-counter medications, vitamins, and herbal supplements.1

Warnings for Defitelio

Defitelio can cause serious side effects, including bleeding, thrombocytopenia, and anaphylaxis. It is important to tell your doctor about any medical conditions you have, including a history of bleeding disorders or a history of allergic reactions.1

Clinical Pharmacology

Defitelio is a polysaccharide-based drug that works by inhibiting the formation of new blood vessels, which can help reduce the risk of VOD. It also has anti-inflammatory and antithrombotic properties, which can help reduce the risk of bleeding.1

Medication Guide

Patients should read the medication guide provided by their healthcare provider before starting treatment with Defitelio. The guide provides important information about the drug, including indications, dosage and administration recommendations, common drug interactions, warnings, and clinical pharmacology.1

Conclusion

Defitelio is an effective medication for treating hepatic veno-occlusive disease in adults and children who are undergoing hematopoietic stem cell transplantation. It is important to follow the dosage and administration recommendations provided by your healthcare provider and to be aware of the potential side effects and drug interactions.1

References:
1. Defitelio (defibrotide sodium) [Package Insert]. Summit, NJ: Jazz Pharmaceuticals, Inc.; 2020.